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M94A2676.TXT
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1994-10-25
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Document 2676
DOCN M94A2676
TI Risk factors for HIV seroconversion among injecting drug users in
Montreal: the Saint-Luc cohort experience.
DT 9412
AU Lamothe F; Bruneau J; Soto J; Lachance N; Franco E; Vincelette J; Fauvel
M; Hopital Saint-Luc, Canada.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):25 (abstract no. 074C). Unique
Identifier : AIDSLINE ICA10/94369899
AB OBJECTIVES: To evaluate HIV seroconversion rates and risk factors in an
open dynamic cohort of injecting drug users (IDUs) in Montreal. METHODS:
Consenting IDUs (all recent injectors) were recruited from the street
and treatment centers in a follow-up cohort. Information and HIV
serology were obtained at each visit. Univariate actuarial analysis of
seroconversion was performed using Kaplan-Meier life time estimators.
RESULTS: From 1988/9 to 1993/2, 55 of 608 negative subjects
seroconverted. Total follow-up was 874 person-years for an incidence
rate per 100 person-years of 6.3% (95% IC: 4.7-8.2). For 3 consecutive
18 months periods, incidence rose from 4.8% (88/9-90/2), 7.5%
(90/3-91/8) to 9.8% (after 91/9) (p = 0.046, Log-rank test). Entry
factors associated with conversion were: street recruitment, previous
imprisonment, cocaine preference, more than 15 injections (last 28
days), attending a needle exchange program at least once, 2 or more
sharing partners, sharing with an HIV+/AIDS partner, and having
HIV+/AIDS acquaintances (all p < 0.05, Log-rank test). Factors not
associated were: sex, booting fresh blood, injecting in shooting
galleries, sexual orientation, prostitution and number of sexual
partners. CONCLUSION: HIV infection seems to progress among IDUs
recruited. Seroconversion is associated with needle sharing behaviours
in spite of risk knowledge and relative availability of sterile
equipment. More research is needed on impulsive determinants of sharing
behaviours.
DE Actuarial Analysis Cohort Studies Female Human HIV
Infections/TRANSMISSION HIV Seropositivity/*EPIDEMIOLOGY Incidence
Male Needle Sharing Quebec/EPIDEMIOLOGY Risk Factors Sex Behavior
Substance Abuse, Intravenous/*COMPLICATIONS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).